KEY PUBLICATIONS

Villoutreix, Bruno (2022), DiPaola, M.,  Tsaioun, K. “A new ChEMBL dataset for the similarity-based target fishing engine FastTargetPred: annotation of an exhaustive list of linear tetrapeptides”, Data in Brief, 2022, Mendeley Data, V1, doi: 10.17632/9t5zdgs3s2.1 https://data.mendeley.com/datasets/9t5zdgs3s2/1

Kayyali US, Ghandakly E, Singh N, Villoutreix BO, Tsaioun K. Kinase  signaling as a drug target modality for regulation of vascular  hyperpermeability: a case for ARDS therapy development. Drug Discov  Today. 2022 Jan 24:S1359-6446(22)00030-7. doi:  10.1016/j.drudis.2022.01.008. Epub ahead of print. PMID: 35085784. 

Singh N, Chaput L, Villoutreix BO. Virtual screening web servers: designing chemical probes and drug candidates in the cyberspace. Brief Bioinform. 2021 Mar 22;22(2):1790-1818. doi: 10.1093/bib/bbaa034.

Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE, Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Sci Rep. 2021 Mar 18;11(1):6403. doi: 10.1038/s41598-021-85708-2. PMID: 33737635; PMCID: PMC7973584. https://doi.org/10.1038/s41598-021-85708-2

Vassiliou AG, Kotanidou A, Dimopoulou I, Orfanos SE. Endothelial Damage  in Acute Respiratory Distress Syndrome. Int J Mol Sci. 2020 Nov  20;21(22):8793. doi: 10.3390/ijms21228793. PMID: 33233715; PMCID:  PMC7699909.

Liu, T., Warburton, R. R., Hill, N. S. & Kayyali, U. S. Anthrax lethal toxin-induced lung injury and treatment by activating MK2. J Appl Physiol (1985) 119, 412–419 (2015).

 Liu, T. et al. Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling. J Cell Physiol 227, 1438–1445 (2012).

Ronkina, N. et al. Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic Acids Res 39, 2503–2518 (2011).

 Liu, T. et al. Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis. Am J Respir Cell Mol Biol 37, 507–517 (2007).

Sousa, A. M. et al. Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2. J Cell Biochem 100, 1581–1592 (2007).

 Kayyali, U. S. et al.Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2. J Biol Chem 277, 42596–42602 (2002).